Tetrabutylammonium Fluoride Trihydrate CAS 87749-50-6 Good

The preparation method of Tetrabutylammonium fluoride trihydrate(TBAF.3H2O) CAS No.:87749-50-6 is as follows: mix potassium hydroxide and methanol in a weight ratio of 0.8-1:1 to obtain a mixed solution, mix tetrabutylammonium bromide and solvent methanol in a weight ratio of 1:2, stir and quickly add the mixed solution of ammonium hydroxide and methanol, continue stirring until the precipitate is completely precipitated, and react for 2 hours; The precipitate was filtered under reduced pressure, and the resulting light yellow liquid was crude tetrabutylammonium hydroxide; Add deionized water to the crude product of tetrabutylammonium hydroxide, heat to reflux, maintain the temperature at 35-50 ℃, react at a constant temperature for 3 hours, cool and crystallize. The resulting white crystals are the finished product, which is stored in a polyethylene container.

Tetrabutylammonium fluoride trihydrate is a deprotection reagent for silicon ether protecting groups, and is often used as a Phase Transfer Catalyst and mild organic base. Reagent for cracking silyl ether and other silane protecting groups using tetrabutylammonium fluoride trihydrate; A catalyst that catalyzes various reactions of silicon complexes.